As suggested in the brief history above, experimentation figured prominently in the rise of molecular biology (see the entry on experiment in biology).
As suggested in the brief history above, experimentation figured prominently in the rise of molecular biology (see the entry on experiment in biology).X-ray crystallography allowed molecular biologists to investigate the structure of macromolecules (see Celebrating Crystallography in Other Internet Resources).This section sketches four facets of molecular biology’s development: its origins, its classical period, its subsequent migration into other biological domains, and its more recent turn to genomics and post-genomics.Tags: A Beautiful Mind Term PaperAssignment InEssays On BiographyStephen Ames EssaysGreat Argument Essay TopicsHow To Brainstorm For An EssayAngry Earlier Essay I I'D Made Science Wish
1966; Fischer and Lipson 1988; Fleming 1968; Lewontin 1968; Luria 1984; Morange 1998: Ch. Delbrueck’s colleague at Cal Tech, Linus Pauling, utilized his knowledge of structural chemistry to study macromolecular structure.
Pauling contributed both theoretical work on the nature of chemical bonds and experimental work using x-ray crystallography to discover the physical structure of macromolecular compounds (Pauling 1939, 1970; Olby 1979; Hager 1995; Crick 1996; Sarkar 1998).
For Schroedinger, biology was to be reduced to the more fundamental principles of physics, while Delbrueck instead resisted such a reduction and sought what made biology unique.
Muller’s shift from Mendelian genetics to the study of gene structure raises the question of the relation between the gene concepts found in those separate fields of genetics.
The field of molecular biology studies macromolecules and the macromolecular mechanisms found in living things, such as the molecular nature of the gene and its mechanisms of gene replication, mutation, and expression.
Given the fundamental importance of these macromolecular mechanisms throughout the history of molecular biology, a philosophical focus on the concept of a mechanism generates the clearest picture of molecular biology’s history, concepts, and case studies utilized by philosophers of science.To investigate the self-reproductive characteristic of life, Delbrueck used bacteriophage, viruses that infect bacteria and then multiply very rapidly.The establishment of “The Phage Group” in the early 1940s by Delbrueck and another physicist-turned-biologist Salvador Luria marked a critical point in the rise of molecular biology (Brock 1990; Cairns et al.Watson and Crick collaborated to build a model of the double helical structure of DNA, with its two helical strands held together by hydrogen-bonded base pairs (Olby 1994).They made extensive use of data from x-ray crystallography work on DNA by Maurice Wilkins and Rosalind Franklin at King’s College, London, appallingly without Franklin’s permission or even knowledge (Maddox 2002), Crick’s theoretical work on crystallography (Crick 1988), and the model building techniques pioneered by Pauling (de Chadarevian 2002; Judson 1996; Olby 1970, 1994, 2009).Watson and Crick’s second paper of 1953, which discussed the genetical implications of their recently discovered (Watson and Crick 1953a) double-helical structure of DNA, used both “code” and “information”: .In more detail, the transfer of information from nucleic acid to nucleic acid, or from nucleic acid to protein may be possible, but transfer from protein to protein, or from protein to nucleic acid is impossible.With the structure of DNA in hand, molecular biology shifted its focus to how the double helical structure aided elucidation of the mechanisms of genetic replication and function, the keys to understanding the role of genes in heredity (see the entries on replication and reproduction and inheritance systems).This subsequent research was guided by the notion that the gene was an “Information” replaced earlier talk of biological “specificity”.Thomas Hunt Morgan and his colleagues utilized the fruit fly, , as a model organism to study the relationship between the gene and the chromosomes in the hereditary process (Morgan 1926; discussed in Darden 1991; Darden and Maull 1977; Kohler 1994; Roll-Hanson 1978; Wimsatt 1992). Muller, recognized the “gene as a basis of life”, and so set out to investigate its structure (Muller 1926).Muller discovered the mutagenic effect of x-rays on , and utilized this phenomenon as a tool to explore the size and nature of the gene (Carlson 1966, 1971, 1981, 2011; Crow 1992; Muller 1927).