As determining how the cancer arrests healthy blood production could have significant ramifications for the design and development of treatments for leukaemia, a multi-disciplinary international team undertook two related, experimentally sophisticated, studies to address this question by studying an aggressive AML model in mice that mimics the disease found in humans. Hawkins), in collaboration with myself and my ex-postdoc Tom Weber who is now at WEHI.
The first study was undertaken by members of Cristina Lo Celso's wet lab at Imperial College London (Olufolake Akinduro, Heather Ang, Myriam Haltalli, Nicola Ruvio, Delfim Duarte, N. To accurately determine the proliferation dynamics of both healthy blood cell production and cancer growth, as well as careful measurements of cell numbers, we implemented a method to measure the rate of cell division in vivo.
Acute myeloid leukaemia (AML) is an aggressive cancer originating from blood cells.
There is an unmet clinical need for more effective therapies as the cure rate of AML is only 5-15% in patients older than 60, and the mainstay of treatment has not changed significantly in the last 30 years.
As the drug in question, Deferoxamine (which is commonly found in Irish clinics as a treatment for hemochromatosis), is approved for human use for a different condition, it is known to be safe.
Thus, as it is already in use, it should, in principle, be possible to progress to clinical trials much quicker (~5 years) than one could with a brand new drug (~10-15 years). Mouse bone marrow showing cancerous cells in red interacting with healthy bloods cells in yellow, and blood vessels in cyan. Person identification from DNA is, by now, a standard tool used for parentage determination, to evaluate chimerism after haematopoietic stem cell transplantation, and in criminal forensics.All cells that are label positive for the second label entered DNA synthesis in the brief window between the labels, which serves as a proxy for the number of cells undergoing division per unit time.Existing hypotheses posited a process whereby the cancer actively shuts down healthy blood production in the bone marrow, but we established that a simpler high-level mechanism was at play (Nature Communications, 2018).Marriage and Money: A Naturalist Reading of the Failure of Relationship and the Plight of Being a Woman in Fashionable New York Society in Selected Works of Edith Wharton and F. How middle powers balance between competing great power interests: The case of South Korea’s foreign policies towards China during the Park Geun-hye administration. Development with culture and identity and regional human rights bodies: A comparison on the concept of development adopted by decisions of the Inter-American Court of Human Rights and the African Commission and Court on Human and Peoples’ Rights in light of indigenous peoples’ self-determined development.The stem cells that are the top of the hierarchy of healthy blood cell production proved most resistant to this process, but were ultimately eliminated.En route, we identified an improved phenotypic characterization of true blood stem cells.Institutions and vessels in East Asia: Exploring a new approach for the study of medieval and early modern wares, applied to the origin of early Ming imperial underglaze blue ceramics and their introduction into Korea.A survey of representative land charters of the Ethiopian Empire (1314-1868) and related marginal notes in manuscripts in the British Library, the Royal Library and the university libraries of Cambridge and Manchester.Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984 | 1983 | 1982 | 1981 | 1980 | 1979 | 1978 | 1977 | 1976 | 1975 | 1974 | 1973 | 1972 | 1971 | 1970 | 1969 | 1968 | 1967 | 1966 | 1965 | 1964 | 1963 | 1962 | 1961 | 1960 | 1959 | 1958 | 1957 | 1956 | 1955 | 1954 | 1953 | 1952 | 1951 | 1950 | 1949 | 1948 | 1947 | 1945 | 1944 | 1943 | 1942 | 1940 | 1939 | 1938 | 1937 | 1936 | 1935 | 1934 | 1933 | 1932 | 1931 | 1930 | 1929The new trade / new growth nexus for late industrialisers : exploring learning-by-doing processes for garment (Cambodia, Bangladesh) and cut-flower (Kenya, Ethiopia) exporters : integrating global value chain and firm-level analyses.Transition in the Japanese Youth Cinema (1956-1960): from the Taiyōzoku Phenomenon to the New Wave. Comparative Analysis, Contextual Parameters and Thematic and Formal Transgressions. The visual representations of Bodhidharma in East Asian art with a special emphasis on the Korean Bodhidharma-paintings and the formation of Bodhidharma's iconography.